Publications

An optimized and validated workflow for developing stable producer cell lines with >99.99% assurance of clonality and high clone recovery

bioRxiv

Julia Scherzinger, Daniel Türk, Fernando Aprile-Garcia, PhD

Dec, 16 2022

Blastic transformation of BCR-ABL1 positive chronic myeloid leukaemia through acquisition of CBFB-MYH11 and mutant KIT

British Journal of Haematology

Shoumariyeh K, Hussung S, Niemöller C, Bleul S, Veratti P, Follo M, Riba J, Philipp U, Palmer JM, Pfeifer D, Pantic M, Meggendorfer M, Hackanson B, Finke J, Haferlach T, Duyster J, Miething C, Becker H, von Bubnoff N

Nov, 23 2022

Gene mutations and clonal architecture in myelodysplastic syndromes and changes upon progression to acute myeloid leukaemia and under treatment

British Journal of Haematology

Stosch JM, Heumüller A, Niemöller C, Bleul S, Rothenberg-Thurley M, Riba J, Renz N, Szarc Vel Szic K, Pfeifer D, Follo M, Pahl HL, Zimmermann S, Duyster J, Wehrle J, Lübbert M, Metzeler KH, Claus R, Becker H

Nov, 23 2022

Molecular spikes: a gold standard for single-cell RNA counting

Christoph Ziegenhain # 1, Gert-Jan Hendriks # 1, Michael Hagemann-Jensen 1, Rickard Sandberg

Nov, 23 2022

Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity

Biomedicines

Rogdakis, T;Charou, D;Latorrata, A;Papadimitriou, E;Tsengenes, A;Athanasiou, C;Papadopoulou, M;Chalikiopoulou, C;Katsila, T;Ramos, I;Prousis, KC;Wade, RC;Sidiropoulou, K;Calogeropoulou, T;Gravanis, A;Charalampopoulos, I;

Jun, 3 2022

Coupling CRISPR interference with FACS enrichment: New approach in glycoengineering of CHO cell lines for therapeutic glycoprotein production

Biotechnology journal

Glinšek, K;Kramer, L;Krajnc, A;Kranjc, E;Pirher, N;Marušič, J;Hellmann, L;Podobnik, B;Štrukelj, B;Ausländer, D;Gaber, R;

Apr, 28 2022

Recent advances in CHO cell line development for recombinant protein production

Drug Discovery Today: Technologies

Tihanyi, B;Nyitray, L;

Apr, 1 2022

Targeting KRAS Regulation with PolyPurine Reverse Hoogsteen Oligonucleotides

International journal of molecular sciences

Psaras, AM;Valiuska, S;Noé, V;Ciudad, CJ;Brooks, TA;

Feb, 14 2022

Anaerobic single-cell dispensing facilitates the cultivation of human gut bacteria

Environmental microbiology

Afrizal, A;Hitch, TCA;Viehof, A;Treichel, N;Riedel, T;Abt, B;Buhl, EM;Kohlheyer, D;Overmann, J;Clavel, T;

Jan, 3 2022

Automated analysis of genomic sequences facilitates high-throughput and comprehensive description of bacteria

ISME Communications

Hitch, T;Riedel, T;Oren, A;Overmann, J;Lawley, T;Clavel, T;

Dec, 1 2021

Next steps after 15 stimulating years of human gut microbiome research

Microbial biotechnology

Clavel, T;Horz, HP;Segata, N;Vehreschild, M;

Nov, 11 2021

Technologies for Single-Cell Printing and Patterning

Handbook of Single-Cell Technologies

Ambhorkar, P;Sakr, M;Kumar, H;Kim, K;

Oct, 29 2021

Quantitation of amiodarone and N-desethylamiodarone in single HepG2 cells by single-cell printing-liquid vortex capture-mass spectrometry

Analytical and bioanalytical chemistry

Cahill, JF;Kertesz, V;

Oct, 1 2021

High-throughput and automation advances for accelerating single-cell cloning, monoclonality and early phase clone screening steps in mammalian cell line development for biologics production

Biotechnology progress

Tejwani, V;Chaudhari, M;Rai, T;Sharfstein, ST;

Sep, 3 2021

Printing Microbial Dark Matter: Using Single Cell Dispensing and Genomics to Investigate the Patescibacteria/Candidate Phyla Radiation

Frontiers in Microbiology

Wiegand, S;Dam, HT;Riba, J;Vollmers, J;Kaster, AK;

Jun, 16 2021

MiMiC: a bioinformatic approach for generation of synthetic communities from metagenomes

Microbial biotechnology

Kumar, N;Hitch, TCA;Haller, D;Lagkouvardos, I;Clavel, T;

Jun, 3 2021

Early-Life Immune System Maturation in Chickens Using a Synthetic Community of Cultured Gut Bacteria

mSystems

Zenner, C;Hitch, TCA;Riedel, T;Wortmann, E;Tiede, S;Buhl, EM;Abt, B;Neuhaus, K;Velge, P;Overmann, J;Kaspers, B;Clavel, T;

May, 18 2021

A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells

Nature Methods

Yu Chen, Carlos A. Tristan, Lu Chen, Vukasin M. Jovanovic, Claire Malley, Pei-Hsuan Chu, Seungmi Ryu, Tao Deng, Pinar Ormanoglu, Dingyin Tao, Yuhong Fang, Jaroslav Slamecka, Hyenjong Hong, Christopher A. LeClair, Sam Michael, Christopher P. Austin, Anton Simeonov & Ilyas Singeç

May, 3 2021

Bisulfite-free epigenomics and genomics of single cells through methylation-sensitive restriction

Communications biology

Niemöller, C;Wehrle, J;Riba, J;Claus, R;Renz, N;Rhein, J;Bleul, S;Stosch, JM;Duyster, J;Plass, C;Lutsik, P;Lipka, DB;Lübbert, M;Becker, H;

Feb, 1 2021

Design and Evaluation of a Tethered, Open Port Sampling Interface for Liquid Extraction-Mass Spectrometry Chemical Analysis

Journal of the American Society for Mass Spectrometry

Walton, CL;Kertesz, V;Cahill, JF;

Jan, 6 2021

Rapid Lentiviral Vector Producer Cell Line Generation Using a Single DNA Construct

Molecular therapy. Methods & clinical development

Chen, YH;Pallant, C;Sampson, CJ;Boiti, A;Johnson, S;Brazauskas, P;Hardwicke, P;Marongiu, M;Marinova, VM;Carmo, M;Sweeney, NP;Richard, A;Shillings, A;Archibald, P;Puschmann, E;Mouzon, B;Grose, D;Mendez-Tavio, M;Chen, MX;Warr, SRC;Senussi, T;Carter, PS;Baker, S;Jung, C;Brugman, MH;Howe, SJ;Vink, CA;

Dec, 11 2020

Methods for Automated Single Cell Isolation and Sub-Cloning of Human Pluripotent Stem Cells

Current protocols in stem cell biology

Vallone, VF;Telugu, NS;Fischer, I;Miller, D;Schommer, S;Diecke, S;Stachelscheid, H;

Dec, 1 2020

Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens

Processes

Pino, P;Kint, J;Kiseljak, D;Agnolon, V;Corradin, G;Kajava, A;Rovero, P;Dijkman, R;den Hartog, G;McLellan, J;Byrne, P;Wurm, M;Wurm, F;

Nov, 25 2020

Methods for Single-Cell Isolation and Preparation

Advances in experimental medicine and biology

Pensold, D;Zimmer-Bensch, G;

Sep, 19 2020

Characterization of CRISPR/Cas9 RANKL knockout mesenchymal stem cell clones based on single-cell printing technology and emulsion coupling assay as a low-cellularity workflow for single-cell cloning

bioRxiv

Groß, T;Jeney, C;Halm, D;Finkenzeller, G;Stark, G;Zengerle, R;Kolaty, P;Zimmermann, S;

Aug, 18 2020

Fast Pathogen Identification Using Single-Cell Matrix-Assisted Laser Desorption/Ionization-Aerosol Time-of-Flight Mass Spectrometry Data and Deep Learning Methods

Analytical chemistry

Papagiannopoulou, C;Parchen, R;Rubbens, P;Waegeman, W;

Jun, 2 2020

Traceable Impedance-Based Dispensing and Cloning of Living Single Cells

SLAS technology

Muller, G;Bonzon, D;Claudinot, S;Rochat, A;Renaud, P;Barrandon, Y;

Jun, 1 2020

Single-cell dispensing and ‘real-time’ cell classification using convolutional neural networks for higher efficiency in single-cell cloning

Scientific reports

Riba, J;Schoendube, J;Zimmermann, S;Koltay, P;Zengerle, R;

Jan, 27 2020

Automated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid Repellency

SLAS technology

Li, C;Niles, DJ;Juang, DS;Lang, JM;Beebe, DJ;

Dec, 1 2019

Simultaneous precise editing of multiple genes in human cells

Nucleic acids research

Riesenberg, S;Chintalapati, M;Macak, D;Kanis, P;Maricic, T;Pääbo, S;

Nov, 4 2019

Effective Acoustic Field Generation in Disposable Dispensing Cartridges for Acoustophoretic Particle Focusin

2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)

Siber, C;Lautscham, L;Schoendube, J;Reichert, P;Stumpf, F;Zimmermann, S;Zengerle, R;Koltay, P;

Jun, 1 2019

Rapid, Untargeted Chemical Profiling of Single Cells in Their Native Environment

Analytical chemistry

Cahill, JF;Riba, J;Kertesz, V;

May, 7 2019

Achieving greater efficiency and higher confidence in single-cell cloning by combining cell printing and plate imaging technologies

Biotechnology progress

Yim, M;Shaw, D;

Nov, 1 2018

Microfluidic technologies for circulating tumor cell isolation

The Analyst

Cho, H;Kim, J;Song, H;Sohn, KY;Jeon, M;Han, KH;

Jun, 25 2018

Highly parallel microbioreactors for cell line development based on well plates with functional lids

d-nb.info

Cheng-Han, T;

Jan, 1 2018

Evaluation of piggyBac-mediated CHO pools to enable material generation to support GLP toxicology studies

Biotechnology progress

Rajendra, Y;Balasubramanian, S;McCracken, NA;Norris, DL;Lian, Z;Schmitt, MG;Frye, CC;Barnard, GC;

Nov, 1 2017

Vereinzelung von prokaryotischen und eukaryotischen Zellen

BIOspektrum

Riba, J;Zimmermann, S;Steimle, B;Gross, A;

May, 1 2017

Molecular Genetic Characterization of Individual Cancer Cells Isolated via Single-Cell Printing

PloS one

Riba, J;Renz, N;Niemöller, C;Bleul, S;Pfeifer, D;Stosch, JM;Metzeler, KH;Hackanson, B;Lübbert, M;Duyster, J;Koltay, P;Zengerle, R;Claus, R;Zimmermann, S;Becker, H;

Sep, 22 2016