C.STUDIO

Simplify Cell Line Development with Intelligent Clone Analysis and Tracking

Dispensing records. Monoclonality images. Growth curves. Cell counts. Titer values. In most CLD labs, these live in separate systems. Connecting them costs time, introduces errors, and delays clone selection.​

​C.STUDIO breaks those data silos. It is the central intelligence layer of the UP.SIGHT and C.STATION ecosystem, a clone-centric platform where dispensing, Day-0 monoclonality imaging, clone growth tracking, cell counting, viable cell density, and titer comes together, so you select your best clones faster with the documentation regulators expect.​

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Why C.STUDIO?

Without C.STUDIO

  • Clone data scattered across instruments and spreadsheets
  • Monoclonality documentation assembled manually, prone to error
  • Cell counting and titer on a separate instrument, disconnected from the campaign
  • Analysis only at the instrument, scientists tied to the bench
  • Hit-picking based on incomplete or partially reconciled information

With C.STUDIO

  • Every workstep centralized in one clone-centric campaign view
  • Regulator-ready reports generated automatically and one click away
  • AI-powered VCD and titer values integrated directly into your campaign data
  • Access your data anywhere: lab, desk, or meeting room
  • Clone selection driven by the complete data picture, in one view
Key Features and Benefits

How C.STUDIO Transforms Your CLD Campaigns

C.STUDIO unifies external data so you can follow every clone from single-cell dispensing through colony growth to titer assessment, even after hit-picking or transfer to a new plate. Select clones for hit-picking, choose your destination plate format, and C.STUDIO generates a pick list mapping each colony to its new position, guiding clone transfer with precision.

C.STUDIO- Follow your top clones journey

One Software. Every Clone Decision.

  • Day-0 dispensing images + clone growth tracking + VCD + titer — all in one campaign view​

  • Easy and data-driven clone selection and hit pick list generation​

  • Regulator-ready monoclonality reports, generated automatically​

  • Access your clone data from any computer on your network​

  • AI-powered cell counting and VCD available today, and single-cell detection coming soon​

Break the Data Silos

One clone-centric view of dispensing images, monoclonality, growth, VCD and titer, to find your clones faster.

Campaign Intelligence, Not Just Data Storage​

The clone, not the plate, at the center. Each clone's full history in one view to sort, filter and rank.

AI-Powered Cell Intelligence, Available Today​

Cell counting and VCD across a 3-log range at CV 3.6-7.0%, with no user-to-user variability, centralized with all clone data.

Visual Proof of Monoclonality — Built for Regulators​

C.STUDIO automatically compiles dispensing images, cell detection records, and growth tracking into regulator-ready monoclonality reports. IND documentation is just one click away.

Designed for CLD Scientists, Not Software Engineers​

C.STUDIO is deliberately lean. Its intuitive workflows and short learning curve keep your team focused on science, not software. From campaign creation to clonality reports, every step is guided.

Work From Anywhere

A centralized data service gives authorized users access to campaign data from any computer on your network.

C.STUDIO's AI Roadmap Is Just Getting Started.​

AI-powered cell counting and VCD are available today. Next: AI-powered single-cell detection at the point of dispensing — bringing a new level of automated, objective confidence to Day-0 monoclonality assurance.​

Available Today

Cell Counting

Detects and counts cells with high accuracy across 3 logs of cell density. It effectively removes the need for replicates across multiple dilutions.​

Viable Cell Density (VCD)​

Quantifies live cells per mL directly in the campaign, from brightfield and fluorescence imaging. Use either a green or red label, for either dead- or live-cell staining​

Coming Soon

AI-powered single-cell detection

Automated, image-based detection of single-cell events at the point of dispensing — extending objective Day-0 monoclonality confidence.​

Automated monoclonality confidence assessment​

AI-derived Areas-of-interest (AoI) enable time-efficient screening of the entire wells area, streamlining the review process for QA and regulatory submissions.​

Tracking Colony Growth

Access all UP.SIGHT-derived data and even external assay data in C.STUDIO, from single cell dispensing to colony growth to titer assessment and more. Never lose sight of your best clones even after hit picking or clone transfers into new well plates. ​

Centralizing confluency, VCD and titer values helps you pinpoint the perfect moment to transfer clones. Simplify your cell culture journey and ensure you make informed decisions every step of the way. ​

​

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AI-powered cell count and VCD

Accurately quantify cell growth with C.STUDIO's advanced cell counting capabilities. Using high-quality images captured by the UP.SIGHT, C.STUDIO delivers reliable cell counts and VCD measurements across a 3-log linear range, from a handful to several thousands cells per well. It makes it easy to compare performance of clones at different growth stage, and make confident decisions throughout your cell line development workflow.

Product-Details_Robust-software-guided-clone-transfer

Follow your clone's journey + Robust software guided clone transfer

Access all UP.SIGHT-derived data and even external data in C.STUDIO and follow your clone’s journey over time. From single cell dispensing to colony growth to titer assessment and more. Never lose sight of your best clones even after hit picking or clone transfers into new well plates.

Select your clones for hit-picking in C.STUDIO and specify their destination well plate format. Generate a detailed pick list, mapping each colony to a specific position on the new plate. This precise guidance simplifies manual clone picking, ensuring a seamless transfer process.  

KEY FEATURES

Get the Most Out of Your CLD Workflows

SPEAK WITH A SPECIALIST

End-to-End Clone Tracking

CYT | Product Details - Follow your top clones journey

End-to-end
clone tracking

Follow every single clone throughout the whole CLD process, no matter if it is transferred from one plate to another. The Multiviewer visualizes acquired images and ranks, identifies and selects your winners. Verify monoclonality for your top clones.

Everything on One Platform

CYT | Documentation to meet regulatory requirements 2

One platform that
does it all and knows it all

Pick your best clones based on UP.SIGHT-derived data including the proof of clonality, confluency, cell count and titer. Cherry on top? Integrate data from custom assays to do your research your way.

Full Visibility, No Doubt

CYT | Tech_Note_24.04_-_AI-powered_Cell_Count_and_VCD_on_the_UP.SI__img-002

Full visibility + no errors

Goodbye tedious comparisons, cross-references, and multi-platform analyses. Welcome to the productivity era – just one software suite with a common database that eliminates manual, error-prone comparison of results in various formats.

Direct Campaign Management

CYT | Documentation to meet regulatory requirements 3

Let the software show you the way

Manage all your CLD campaigns in one place – never lose track of your work.

C.STUDIO’s software-guided clone picking, and transfer capabilities support you in manual pipetting by creating clone transfer lists.

Regulatory Compliance + Security Support

CYT | Documentation to meet regulatory requirements 1

Supporting 21 CFR
Part 11 compliance

C.STUDIO ensures data integrity by embedding airtight security mechanisms to give your lab complete confidence.

On-demand generation of clonality reports to prove clonal derivation of your cell line for IND and BLA submissions.

CYT | Product Details - Follow your top clones journey

End-to-end
clone tracking

Follow every single clone throughout the whole CLD process, no matter if it is transferred from one plate to another. The Multiviewer visualizes acquired images and ranks, identifies and selects your winners. Verify monoclonality for your top clones.

CYT | Documentation to meet regulatory requirements 2

One platform that
does it all and knows it all

Pick your best clones based on UP.SIGHT-derived data including the proof of clonality, confluency, cell count and titer. Cherry on top? Integrate data from custom assays to do your research your way.

CYT | Tech_Note_24.04_-_AI-powered_Cell_Count_and_VCD_on_the_UP.SI__img-002

Full visibility + no errors

Goodbye tedious comparisons, cross-references, and multi-platform analyses. Welcome to the productivity era – just one software suite with a common database that eliminates manual, error-prone comparison of results in various formats.

CYT | Documentation to meet regulatory requirements 3

Let the software show you the way

Manage all your CLD campaigns in one place – never lose track of your work.

C.STUDIO’s software-guided clone picking, and transfer capabilities support you in manual pipetting by creating clone transfer lists.

CYT | Documentation to meet regulatory requirements 1

Supporting 21 CFR
Part 11 compliance

C.STUDIO ensures data integrity by embedding airtight security mechanisms to give your lab complete confidence.

On-demand generation of clonality reports to prove clonal derivation of your cell line for IND and BLA submissions.

CSTUDIO Banner
RESOURCE HIGHLIGHT

Validated in Real-World Cell Line Development

C.STUDIO software is embedded across CYTENA's solutions and has played a fundamental role in advancing cell-line development applications. Discover more about C.STUDIO's impact to learn more on how and why this software can support you in your CLD automation journey.

APPLICATION NOTE

UP.SIGHT™ – AI-powered Cell Count and VCD

An introduction to the AI‑driven, plate‑based VCD assessment on UP.SIGHT™ 2nd Gen. Learn how C.STUDIO centralizes VCD, titer, monoclonality proof, and growth‑tracking images.

 

Read Now →

WEBINAR

10× Faster VCD, One-Tenth the Pipette Tips: How AI Is Rewriting Cell Counting in CLD

Discover the innovative way to execute cell counting in CLD applications with the implementation of AI software. 

 

Watch Now →

Related Applications

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Generate well-characterized engineered cell clones with greater confidence in single-cell origin.

MONOCLONAL ANTIBODIES

Accelerate selection of high-performing monoclonal cell lines for antibody production.

ALL APPLICATIONS

Related Products

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Automate cell line development–integrating single-cell isolation, imaging and clone selection into one efficient, compliant workflow.

UP.SIGHT

Single-cell dispenser with fluorescence and plate imaging for double-assured monoclonality.

C.SIGHT

Fast, label-free single-cell isolation engineered for high viability and outgrowth.

F.SIGHT

Dual-channel fluoroscent and brightfield sorting for precise isolation of labeled cells.

ALL SINGLE-CELL DISPENSERS
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Frequently Asked Questions

What is C.STUDIO?

C.STUDIO is CYTENA's clone-centric cell line development software. It centralizes everything for each clone — dispensing images, day-0 to day-X growth tracking, viable cell density and titer — so clone tracking and selection happen in one place, and produces regulator-ready monoclonality reports.

When can I measure viable cell density (VCD) after cloning?

Weeks earlier than usual. UP.SIGHT's AI-based VCD reads freshly cloned, low-density wells that standard counters can't —  across a 3-log linear range at under ~7% CV, up to 384 wells per run — so you rank and cut clones from the earliest outgrowth and combine that data with titer measured with F.QUANT as early as Day-14.

Can I measure titer / productivity to rank clones early?

Yes. F.QUANT quantifies antibodies, Fc-fusion proteins and Fab fragments directly on the system. Paired with CYTENA's AI-enabled early VCD, it gives specific productivity (titer per viable cell) as early as Day-14, so you rank clones on real data instead of waiting for high-density readouts.

Does the system track colony growth from day 0?

Yes. Well-bottom imaging on the UP.SIGHT follows each clone rom day 0 to day X, measuring confluency or cell count for both adherent and suspension cells, so growth history informs clone selection — all recorded in C.STUDIO.

Is the AI analysis run on-instrument or in the cloud?

On-instrument. AI-based cell counting and VCD run locally on the AI.SIGHT workstation — no cloud upload, no black box — keeping your data in-house.