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“Axxam has revolutionized the limiting dilution process with the UP.SIGHT instrument over the past year. We experienced the power of this remarkable tool with its intuitive interface and double assurance of clonality, enabling us to accelerate the production of stable monoclonal cell lines expressing a diverse range of targets for our high-throughput screening campaigns.”

“UP.SIGHT is a very gentle and reliable cell dispensing system that allows for automation of assuredly monoclonal cell line generation with our very large and fragile protoplasts. The UP.SIGHT is easy to handle and easy to integrate into the existing lab due to its small footprint.”

“The instrument [B.SIGHT] is handy and super user-friendly. The machine is ready to sort after a quick quality control step and adaption of sort settings. It sorts single cells reliably. Due to the usage of cartridges cross-contamination is not an issue anymore and cells are sorted alive and happy since they are kept in their needed buffer during the entire sort process. An in-built laser enables us to differentiate between fluorescently labelled and unlabelled cells, which makes the whole cell sorting process even more precise.”

“We can isolate one cell, one clone that has the exact desired genome, and we need to prove from a regulatory purpose that there is just one cell in any well. For this purpose, we selected the UP.SIGHT, where we make use of the double clonality assurance to be confident in the results

"The F.SIGHT device is easy to use and, thanks to the use of sterile cartridges, does not require any complex cleaning procedures and prevents cross-contamination. The cells to be dispensed can be selected and reliably dispensed on the basis of size, roundness and fluorescence. The dispensing of the individual cells is documented with the aid of a camera, which also provides good quality control and documentation for each cell afterwards. Due to its small size, the F.sight can be operated in a sterile bench.”

"Single cell efficacy: 70-93%; Colony efficacy: 58-91% (after optimization). The plating effort (to get single cells) can be lowered compared to limited dilution and FACS single cell deposition by the factor 4-5."

"Pro: High precision of single-cell printing and strong confidence of monoclonality. Automation API and excellent technical support. Con: Manual sample loading, medium throughput, occasional cartridge-to-cartridge variations."

“This instrument is a very reliable, cost-efficient and gentle cell dispensing system, which greatly reduces premature cell lysis and avoids debris, duplets, and clumps through its sophisticated optical control parameters. Cells can be efficiently selected based on size and roundness. In addition, the f.sight optionally allows the use of fluorescence as an optical selection parameter for gentle selection of e.g. GFP-labelled or antibody stained cells.”

"When using the single-cell printer, the number of monoclonal cell lines increased 6-fold compared to the limiting dilution process, therefore increasing the number of pools that could be cloned. By implementing both of these technologies, the cell line development process can be decreased from 9 months to 6 months."

"ExcellGene SA relies on the Cytena Single Cell Dispenser, which offers both single cell dispensing and imaging capabilities. This technology provides documented evidence of clonality for all dispensed cells, ensuring the integrity and reliability of the resulting cell lines. The user-friendly nature of Cytena devices makes them invaluable tools for streamlining and optimizing laboratory workflows."