G.PURE

Contact-Free Magnetic Bead Processing - DNA Purification

G.PURE automates nucleic acid purification using patented centrifugal liquid evacuation technology. Designed for high-throughput NGS and PCR workflows, it delivers consistent recovery, high sample quality, and efficient magnetic bead cleanup while reducing hands-on time and operating costs.
 
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BENEFITS

Automated Centrifugal Purification for NGS and PCR Workflows

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High-Quality Sample Processing

Automated magnetic bead purification delivers consistent nucleic acid recovery and high sample quality, helping minimize workflow variability and support reliable downstream sequencing and PCR analysis.

Fast & Reproducible Processing

G.PURE automates magnetic bead cleanup workflows in 96- and 384-well PCR plates, enabling rapid processing with consistent recovery and reproducible results.

Sustainable and Cost Efficient

Patented centrifugal liquid evacuation technology eliminates the need for disposable plastic tips during liquid removal, helping reduce plastic waste and consumable costs while supporting more sustainable laboratory workflows.

Automation-Ready

Designed for modern laboratory automation environments, G.PURE supports SiLA 2 communication and integration with third-party automation platforms, enabling streamlined nucleic acid purification workflows and scalable high-throughput processing.

HIGHLIGHTS

Calculate Your Cost Savings

G.PURE helps reduce plastic waste and consumable costs by eliminating the need for disposable pipette tips.

Compared with manual pipetting and conventional tip-based systems, reduced tip consumption can significantly lower recurring operating expenses. Combined with fast, reproducible purification workflows, these savings can help offset the investment in G.PURE over time.

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G.PURE GEN 2 Internal View

 

WORKFLOW

How it Works, Step-by-Step

G.PURE uses patented centrifugal liquid evacuation and contact-free dispensing technologies to automate magnetic bead purification workflows. By replacing traditional aspiration-based liquid removal, the system enables rapid, reproducible nucleic acid cleanup with reduced consumable usage. The workflow can be broken down into four simple steps:

Prepare and Load the PCR-plate

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Step 1. Prepare and Load the PCR-plate

Combine sample and magnetic beads, then load the PCR plate into G.PURE.

Supernatant Removal by Centrifugal Force

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Step 2. Supernatant Removal by Centrifugal Force

Controlled centrifugal liquid evacuation removes the supernatant efficiently and reproducibly without manual aspiration.

Ethanol Washes

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Step 3. Ethanol Washes

Contact-free dispensing adds ethanol to the sample, while centrifugal liquid evacuation rapidly removes ethanol for efficient purification.

 

Bead Drying and Elution

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Step 4. Bead Drying and Elution

The purified plate is returned with dried magnetic beads, ready for automated elution using the integrated precision dispensing system and downstream processing.
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Step 1. Prepare and Load the PCR-plate

Combine sample and magnetic beads, then load the PCR plate into G.PURE.

DISPENDIX_G.PURE_Beautyshot_0006

Step 2. Supernatant Removal by Centrifugal Force

Controlled centrifugal liquid evacuation removes the supernatant efficiently and reproducibly without manual aspiration.

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Step 3. Ethanol Washes

Contact-free dispensing adds ethanol to the sample, while centrifugal liquid evacuation rapidly removes ethanol for efficient purification.

 

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Step 4. Bead Drying and Elution

The purified plate is returned with dried magnetic beads, ready for automated elution using the integrated precision dispensing system and downstream processing.
RESOURCES

Accelerating Workflows Across the World

Researchers worldwide rely on G.PURE to simplify automated nucleic acid purification while improving workflow efficiency and reducing consumable costs. Explore our featured resources below to learn more about G.PURE and its applications in NGS and PCR workflows.
BLOG

How the G.PURE is Advancing Automated Sample Prep

 Discover the G.PURE, an automated clean-up device transforming NGS workflows with precision, sustainability, and reproducibility. 

 

 

 

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APPLICATION NOTE

AMPure Beads and Beyond: Automated Bead-based DNA Cleanup at Scale

In this Application Note, we show how the G.PURE combined with the I.DOT enables consistent, scalable, and cost-effective bead-based cleanup across applications. 

 

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Related Applications

GENE THERAPY

Viral vector development, delivery system optimization, and advanced genomic medicine.

SYNTHETIC BIOLOGY

Design, assembly, and optimization of novel genetic constructs and metabolic pathways.

SINGLE-CELL OMICS

High-resolution genomic and transcriptomic analysis of cellular heterogeneity.

TESTIMONIALS

Trusted by Pharma, Industry, and Academia

“Axxam has revolutionized the limiting dilution process with the UP.SIGHT instrument over the past year. We experienced the power of this remarkable tool with its intuitive interface and double assurance of clonality, enabling us to accelerate the production of stable monoclonal cell lines expressing a diverse range of targets for our high-throughput screening campaigns.”

Axxam-SpA-logo
Principal Scientist, Axxam Paola Picardi

“UP.SIGHT is a very gentle and reliable cell dispensing system that allows for automation of assuredly monoclonal cell line generation with our very large and fragile protoplasts. The UP.SIGHT is easy to handle and easy to integrate into the existing lab due to its small footprint.”




eleva logo
Strain Development, Scientist, eleva Nicola Krieghoff

“We can isolate one cell, one clone that has the exact desired genome, and we need to prove from a regulatory purpose that there is just one cell in any well. For this purpose, we selected the UP.SIGHT, where we make use of the double clonality assurance to be confident in the results.”



cellistic_logo
Director of Genom Engineering, Cellistic Suzanne Snellenberg

Related Products

C.WASH PLUS

Centrifugal plate washing system, compatible for 96-, 384-, and 1536-well plates.

I.DOT

Tipless, low-volume non-contact dispensing with the I.DOT for fast, precise liquid handling with minimal waste across life science applications.

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Frequently Asked Questions

What does the G.PURE automate?

The G.PURE automates bead‑based cleanup steps, including supernatant removal, ethanol washing, controlled bead drying, and elution buffer dispensing for DNA and RNA aliquots. Bead addition and downstream elution transfer are not part of the automated process.  

Is the G.PURE a DNA extraction system?

No. The G.PURE is designed for post‑amplification or library‑prep cleanup, size selection, and wash steps in NGS and PCR workflows. For single‑cell DNA applications, DNA capture or amplification must be completed before using the G.PURE.  

Which plate formats are supported?

The G.PURE supports low‑profile and high‑profile 96‑well and 384‑well PCR plates. 

Does the G.PURE require pipette tips or an external liquid handler?

No. The G.PURE operates as a fully tip‑free system using centrifugal liquid evacuation and integrated, contact‑free dispensing. No external pipetting robot is required for its core cleanup functions.  

Which magnetic bead chemistries are compatible?

The G.PURE does not require proprietary beads and is compatible with common ferromagnetic bead chemistries used for NGS cleanup and size selection, including AMPure XP‑type beads and equivalents. 

How long does a typical cleanup take?

The cleanup step itself can be completed in approximately two minutes for both 96‑well and 384‑well plates. The bead binding duration is not included in this time.