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Genomics

Miniaturization and Automation of a full-length Single-Cell RNA-seq Workflow

Full-length single-cell RNA-seq is often limited by high reagent use and labor-intensive workflows. In this study, the F.SIGHT™ was used to isolate single HEK293FT cells into 384-well PCR plates, followed by automated miniaturized library preparation with the I.DOT™. Our findings demonstrate that the F.SIGHT and I.DOT provide a scalable and cost-efficient platform for high-quality, full-length scRNA-seq. […]

Miniaturization and Automation of a full-length Single-Cell RNA-seq Workflow Read More »

Using the C.WASH™ to conduct automated, non-contact bead-based DNA purification

Magnetic bead cleanup is a manual bottleneck in scRNA-seq workflows, often increasing time and tip consumption. The C.WASH automates this step: it uses centrifugal force to gently remove liquids while retaining magnetic beads, then dispenses wash reagents non-contact, reducing cross-contamination. In a test with alternating human and mouse cells in 384-well plates, C.WASH showed no cross-species contamination

Using the C.WASH™ to conduct automated, non-contact bead-based DNA purification Read More »

Fast, Miniaturized and Automated Library Prep for High-quality Single-cell RNA-seq Data

The F.SIGHT™ was used to isolate single HEK293FT cells into 384-well PCR plates, followed by automated miniaturized library preparation with the I.DOT™. Reaction volumes were reduced to one-tenth of the standard, enabling cost-efficient full-length scRNA-seq. This workflow shows how the F.SIGHT together with the I.DOT enable precise single-cell isolation and high-quality sequencing in a scalable,

Fast, Miniaturized and Automated Library Prep for High-quality Single-cell RNA-seq Data Read More »

The C.WASH™ Enables Automated and Tip-free Bead-based DNA Purification with Uniform Results and No Cross-Contamination

Automated, tip-free bead-based DNA purification accelerates NGS library preparation while eliminating cross-contamination risks. In this study, the C.WASH gently removed wash buffers via centrifugal force, maintained magnetic beads during cleaning, and uniformly dispensed reagents – avoiding well-to-well contamination and saving over a thousand pipette tips per run. These results underscore the C.WASH as a highly efficient and

The C.WASH™ Enables Automated and Tip-free Bead-based DNA Purification with Uniform Results and No Cross-Contamination Read More »

C.WASH™ allows fast, tip-free bead-based DNA purification for single cell RNA-sequencing

Current scRNA-seq workflows are hindered by manual, tip-consuming bead cleanup steps that introduce variability and inefficiency. The C.WASH non-contact plate washer and liquid dispenser automates bead-based DNA purification using centrifugal removal of liquids and integrated reagent dispensing. In tests using alternating rows of human and mouse single cells in 384-well plates, C.WASH eliminated cross-sample contamination and

C.WASH™ allows fast, tip-free bead-based DNA purification for single cell RNA-sequencing Read More »

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CYTENA is a part of BICO. BICO is a lab automation partner and provider of selected workflows to pharma and biotech. Operating through two business areas – Lab Automation and Life Science Solutions – BICO strives towards the vision to enable and automate the life science lab of the future.

Read more at BICO.com

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