Liquid Handlers

Automated Liquid Handling

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What are Liquid Handlers?

Liquid Handlers are laboratory instruments that automate the accurate transfer of liquids across volumes ranging from nanoliters to milliliters. Available as manual, semi-automated, or fully automated liquid handling systems, they improve precision, reduce manual pipetting, and streamline laboratory workflows.

Automated liquid handlers play a critical role in laboratory automation by increasing throughput, minimizing human error, and supporting applications in biotechnology, pharmaceuticals, diagnostics, genomics, drug discovery. and beyond

Benefits

I.DOT: Your Non-Contact Liquid Handler

The I.DOT helps researchers improve precision, reduce reagent consumption, and simplify low-volume liquid handling workflows. Its innovative, non-contact dispensing technology accurately delivers volumes as low as 8 nL, eliminating the need for disposable pipette tips while reducing the risk of cross-contamination.

Designed to fit seamlessly into existing workflows, the I.DOT features a dispensing resolution of 0.1 nL that enables reaction miniaturization, minimizes dead volume, lowers reagent costs, and reduces plastic waste—all without compromising performance.

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IDOT Lab LR

Speed

Dispenses 10 nanoliters across a 96-well plate in 10 seconds and across a 384-well plate in 20 seconds.

Liquid Class Range

Supports a broad range of liquid types with predefined dispensing settings, including PCR reagents, magnetic beads, antibodies, DMSO, and glycerol (up to 65%)—configurable at the individual well level.

Non-Contact

Droplets are dispensed into the target plate below the source plate which eliminates carryover and cross-contamination.

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Improved Reproducibility

DX _ I.DOT LT-1

Improved Reproducibility 

Consistency is essential in scientific research. Automated systems follow programmed protocols exactly, ensuring that experiments can be replicated with the same conditions across runs, users, and even different lab locations. 

Enhanced Accuracy and Precision

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Enhanced Accuracy and Precision 

Automated liquid handlers deliver highly precise and reproducible liquid transfers, even at very small volumes. This minimizes variability between samples and ensures consistent experimental outcomes, especially critical in applications such as drug discovery and genomics.  

Reduced Human Error

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Reduced Human Error 

Manual pipetting is prone to inconsistencies caused by fatigue, technique differences, and repetitive strain. Liquid handling automation eliminates many of these variables, leading to fewer errors and more dependable data.  

Time and Cost Efficiency

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Time and Cost Efficiency 

By automating repetitive tasks, lab personnel can focus on higher-value activities such as data analysis and experimental design. Over time, this leads to reduced labor costs and improved overall productivity. 

DX _ I.DOT LT-1

Improved Reproducibility 

Consistency is essential in scientific research. Automated systems follow programmed protocols exactly, ensuring that experiments can be replicated with the same conditions across runs, users, and even different lab locations. 

I.DOT_LT_BS_15

Enhanced Accuracy and Precision 

Automated liquid handlers deliver highly precise and reproducible liquid transfers, even at very small volumes. This minimizes variability between samples and ensures consistent experimental outcomes, especially critical in applications such as drug discovery and genomics.  

DISPENDIX_G.PURE_Beautyshot_0007

Reduced Human Error 

Manual pipetting is prone to inconsistencies caused by fatigue, technique differences, and repetitive strain. Liquid handling automation eliminates many of these variables, leading to fewer errors and more dependable data.  

DISPENDIX_G.PURE_Beautyshot_0009

Time and Cost Efficiency 

By automating repetitive tasks, lab personnel can focus on higher-value activities such as data analysis and experimental design. Over time, this leads to reduced labor costs and improved overall productivity. 

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KEY RESOURCES

Validated in Real-World Cell Line Development

Liquid handlers streamline cell-line development by automating precise reagent, media, and cell dispensing throughout the workflow. From transfection and clone screening to cell expansion and assay preparation, they improve reproducibility, reduce manual errors, and enable high-throughput processing, helping researchers accelerate the development of stable, high-quality cell lines.

APPLICATION NOTE

Maximizing Efficiency and Sustainability for NGS Library Preparation: 1:5 Miniaturization of Illumina DNA Prep 

Miniaturization of library prep workflows remains as an ongoing achievement for many researchers as it saves cost and time.  

 

 

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APPLICATION NOTE

AMPure Beads and Beyond: Automated Bead-based DNA Cleanup at Scale

Bead-based clean ups have become the standard way to purify library samples to obtain desired fragment lengths. Scaling this process can be accomplished by selecting the right automated technologies.

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WEBINAR

G.PURE GEN 2 - Automated, Tipless Magnetic Bead-Based DNA Purification

Dive deeper into the release of the new G.PURE GEN 2 and how this technology is reinventing the way we perform DNA purification and bead-based clean ups.

 

 

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WEBINAR

Precise Liquid Handling for Synthetic Biology: Practical Workflows with the I.DOT

Discover how the I.DOT, our non-contact liquid handling dispenser, has advanced synthetic biology research. 

 

 

 

 

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Related Applications

Cell-Line-Development

CELL LINE DEVELOPMENT

Generate stable, high-producing monoclonal cell lines with the support of a powerful liquid handler for all dispensing processes.

overview-cell-based-assays

ASSAY DEVELOPMENT & OPTIMIZATION

Improve DoE (design of experiments) for drug discovery assays with enhanced automated reagent dispensing.

Gene-Therapy

GENE THERAPY

Generate well-characterized engineered cell clones with greater confidence in single-cell origin with an automated dispensing system.

Protein-expression-in-microbial-systems-2-scaled

SYNTHETIC BIOLOGY

Accelerate the development of new biological parts, systems, and devices at a molecular level.

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Frequently Asked Questions

What is a liquid handler?

A liquid handler is an automated laboratory instrument designed to precisely dispense, transfer, and mix liquids in workflows such as sample preparation, assay setup, and reagent distribution.  

How does a liquid handling system work?

Liquid handlers use pipetting technologies (air displacement, positive displacement, or non-contact dispensing) combined with robotic movement to transfer liquids between plates, tubes, or reservoirs. 

What is the difference between contact and non-contact dispensing?

Contact dispensing touches the liquid surface or container, while non-contact dispensing (like acoustic or droplet-based systems) transfers liquid without physical contact, reducing contamination risk.  

Can liquid handlers handle viscous or volatile liquids?

Yes, but performance depends on the dispensing technology. Some systems are specifically designed to handle challenging liquids more effectively. The I.DOT includes a wide range of liquid classes that are optimized to dispense all kinds of reagents.  

Do liquid handlers require programming?

Some systems require scripting, while others offer user-friendly software with drag-and-drop interfaces. Our systems (I.DOT series), do not require any user programming and can be integrated into new or existing workflows from day 1.  

What is the future of liquid handling automation?

The future lies in miniaturization, increased automation, AI-driven workflows, and integration with fully autonomous labs.