Cell Therapy & Stem Cells

Cell therapy is a field of regenerative medicine that uses living cells, including stem cells and engineered immune cells, to treat disease and repair damaged tissues. The development of these therapies relies on stable, well-characterized cell lines and scalable cell engineering workflows.

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Advancing Cell Therapy Through Stem Cell Research and Clonal Cell Development

Cell therapy and stem cell research focus on understanding, developing, and applying living cells for regenerative medicine and disease treatment. Stem cells are of particular interest due to their ability to self-renew and differentiate into specialized cell types, making them valuable tools for disease modeling, drug discovery, tissue engineering, and the development of novel therapies.

To support these applications, researchers must identify, isolate, and characterize cell populations with the desired properties. Establishing clonal cell lines from single cells helps ensure genetic consistency and reproducibility, while ongoing characterization and expansion are critical for downstream research and therapeutic development.

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Featured Workflow

Cell Isolation and Growth Analysis

The UP.SIGHT single-cell dispensing platform gently isolates single stem cells into 96- or 384-well plates, confirmed by nozzle and well-bottom imaging at the point of dispensing.

1. Suspended cells of interest after initial expansion

2. Single-cell isolation

Solution: UP.SIGHT

3. Clone Expansion

4. Growth Analysis

Solution: UP.SIGHT

iPSC Single-cell Cloning and Cell Line Engineering

Induced pluripotent stem cell (iPSC) engineering combines cellular reprogramming with single-cell cloning to establish well-defined iPSC lines for research and therapeutic development.

Single-cell isolation enables the generation of clonal iPSC populations, supporting genetic consistency, controlled differentiation, and reproducible stem cell research. 

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Clonal Selection and Expansion for Cell Therapy Development

This process focuses on isolating and expanding well-defined stem cell–derived populations for research and translational applications.

Single-cell derived clones are evaluated for stability, viability, and differentiation potential before being expanded into consistent populations for use in regenerative medicine and cell-based therapy research. 

Single-cell Derived Colony Selection and Characterization Workflows

This workflow focuses on the formation and evaluation of colonies originating from individual stem cells or stem cell–derived populations.

Early growth behavior, morphology, and differentiation patterns are assessed to ensure reproducible and well-defined populations for downstream stem cell research and development.

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Application Notes

APPLICATION NOTE

The UP.SIGHT™ enables gentle single cell clonal expansion of human iPSCs with high clone recovery

Gentle, high-recovery single-cell cloning of human iPSCs with built-in imaging-based verification of clonality.

 

 

 

 

 

 

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APPLICATION NOTE

Streamlined Workflow for the Generation of CRISPR-edited Mesenchymal Stem Cell Clones for Regenerative Medicine Applications

The findings highlight the F.SIGHT as a high-throughput, gentle, and precise platform for generating CRISPR-edited monoclonal stem cell lines.

 

 

 

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APPLICATION NOTE

Combined Single-cell Dispensing and 3D Full Well Imaging for Cell Lines with >99.99% Probability of Monoclonality

How the UP.SIGHT combines double verification of single-cell dispensing, via nozzle imaging and novel 3D full-well imaging, to confirm monoclonality (>99.99%) without centrifugation or fluorescent labeling.

 

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More Resources

BLOG

Therapeutic Potential of iPSC-derived Allogeneic Cell Therapies: A Game Changer in Regenerative Medicine

Induced pluripotent stem cells (iPSCs) are revolutionizing biomedical research and healthcare by enabling the generation and modification of virtually any cell type to suit various applications. In this blog, we dive deeper into the potential of iPSC-derived cell therapies.

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WEBINAR

Beyond the Bottleneck: A Leap in Automated Cell Line Engineering with bit.bio

In this webie explore a revolutionary leap in cell line development. A major bottleneck in the cell line engineering field has been the use of manual single-colony isolation of engineered iPSCs. 

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Products for Cell Therapy

UP.SIGHT

Single-cell dispenser with fluorescence and plate imaging for double-assured monoclonality.

C.STATION

Automate cell line development–integrating single-cell isolation, imaging and clone selection into one efficient, compliant workflow.

F.SIGHT

Dual-channel fluoroscent and brightfield sorting for precise isolation of labeled cells.

C.SIGHT

Fast, label-free single-cell isolation engineered for high viability and outgrowth.

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