I.DOT

Non-Contact Liquid Handler

Combining 0.1 nL dispensing resolution, integrated volume verification, and exceptional viscosity-range compatibility, the I.DOT sets a new standard for liquid handling automation, empowering researchers to achieve unprecedented precision, efficiency, and flexibility.

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BENEFITS

Enhance your Automation Arsenal with the I.DOT

Trusted by scientists and labs across the globe, the I.DOT delivers efficient and reproducible liquid handling for all scientific workflows and applications.

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Confidence in your Results

Compatible with any SBS format target labware, dispense 8 nL to 30 μL with 0.1 nL resolution with <=5% precision.

Sustainable, Environmentally-Friendly

Non-contact dispensing forgoes the need for traditional plastic pipette tips, providing significant savings on the total cost of consumables.

Start your Runs with Ease

Features a robust software that is easy to learn and understand. Intuitively create your next protocol in minutes.

Miniaturization-Ready

Conserve your reagents with <1 μL dead volume dispenses, enabling miniaturized workflows

Integrated Volume Verification

Includes dispensing technology that verifies volume and re-dispenses missed droplets.

Return On Investment

Ability to dispense up to 384 source liquids per run with speed and precision.

HIGHLIGHTS

Insert Source Plate and Press Run

The I.DOT is an intuitive non-contact liquid handling system designed to make precision dispensing accessible to researchers of all experience levels. Capable of dispensing volumes as low as 8 nL with exceptional accuracy, speed, and precision, it helps laboratories reduce reagent consumption, minimize plastic waste, and streamline everyday workflows.

Whether you're dispensing sensitive enzymes and magnetic beads for NGS/PCR workflows, or delivering compounds and buffers for high-throughput screening, the I.DOT provides reliable, reproducible performance across a wide range of applications. With simplified operation and highly consistent dispensing, researchers can accelerate sample preparation, improve experimental reproducibility, and focus more on discovery than manual liquid handling.

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I.DOT S

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Developed for Flexibility and Integration-Ready

The I.DOT S is our flagship liquid handling dispenser, optimized to support a wide range of applications. It's flexibility to perform standard reagent dispensing and customized dilutions, makes the I.DOT S our top-selling system.

Full Viscosity Range from Methanol to 65% Glycerol
Up to 96 Source Wells with 1 μL Dead Volume
80 μL Source Well Capacity

I.DOT LT

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Designed For Labs of All Sizes

The I.DOT LT is optimized for accessibility and precision with the device taking up less space in the lab and portable for movement.

Viscosity range from H2O to 43% Glycerol
12 Source Wells with 1 μL Dead Volume
490 μL Source Well Capacity

I.DOT L

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Advancing Genomics Workflows

The I.DOT L is optimized for genomic applications like next-generation sequencing (NGS), personalized medicine, and synthetic biology. The newly improved L.150 consumable elevates the system's viscosity range to dispense reagents like 65% Glycerol, NGS library prep mastermixes, and magnetic beads with ease.

Viscosity Range from Water to 65% Glycerol
Up to 96 Source Wells with 1 μL Dead Volume
500 μL Source Well Capacity

I.DOT HT

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Streamline Drug Discovery

The I.DOT HT is optimized for drug discovery workflows with the capability to dispense reagents like DMSO which is widely used in dose response curves and high-throughput screenings (HTS).

Designed to dispense DMSO & Aqueous Solutions
Up to 384 Source Wells with 5 μL Dead Volume
80 μL Source Well Capacity

I.DOT-Front-View-G.STATION-White

Developed for Flexibility and Integration-Ready

The I.DOT S is our flagship liquid handling dispenser, optimized to support a wide range of applications. It's flexibility to perform standard reagent dispensing and customized dilutions, makes the I.DOT S our top-selling system.

Full Viscosity Range from Methanol to 65% Glycerol
Up to 96 Source Wells with 1 μL Dead Volume
80 μL Source Well Capacity

Download Spec Sheet

I.DOT_LT_PACKSHOTS_Alpha_0003

Designed For Labs of All Sizes

The I.DOT LT is optimized for accessibility and precision with the device taking up less space in the lab and portable for movement.

Viscosity range from H2O to 43% Glycerol
12 Source Wells with 1 μL Dead Volume
490 μL Source Well Capacity

Download Spec Sheet

I.DOT-Front-View-G.STATION-White

Advancing Genomics Workflows

The I.DOT L is optimized for genomic applications like next-generation sequencing (NGS), personalized medicine, and synthetic biology. The newly improved L.150 consumable elevates the system's viscosity range to dispense reagents like 65% Glycerol, NGS library prep mastermixes, and magnetic beads with ease.

Viscosity Range from Water to 65% Glycerol
Up to 96 Source Wells with 1 μL Dead Volume
500 μL Source Well Capacity

Download Spec Sheet

I_DOT_HT_01-1-1024x576

Streamline Drug Discovery

The I.DOT HT is optimized for drug discovery workflows with the capability to dispense reagents like DMSO which is widely used in dose response curves and high-throughput screenings (HTS).

Designed to dispense DMSO & Aqueous Solutions
Up to 384 Source Wells with 5 μL Dead Volume
80 μL Source Well Capacity

Download Spec Sheet

RESOURCES

Validated in Real-World Cell Line Development

Cell line development requires exceptional precision and consistency across every stage of the workflow, from cell seeding and media optimization to clone screening and assay preparation. The I.DOT enables researchers to accurately dispense cells, growth factors, compounds, and other sensitive reagents at nanoliter volumes without physical contact, preserving cell viability while minimizing reagent consumption. By delivering highly reproducible liquid handling and supporting assay miniaturization, the I.DOT helps streamline cell line development workflows, accelerate experimental optimization, and generate reliable data that advances the development of high-performing cell lines.

APPLICATION NOTE

Improving Long-Term Compound Storage in I.DOT Source Plates

Learn how DISPENDIX I.DOT source plates ensure long-term compound stability for drug discovery in our new application note.

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BLOG

Choosing the Right Liquid Handling Platform: Metrics That Matter

Reading vendor spec sheets is generally not enough to understand if a liquid handling system will be compatible with your research workflows.

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WEBINAR

Precise Liquid Handling for Synthetic Biology – Practical Workflows with the I.DOT

Discover how the I.DOT streamlines synthetic biology workflows from a real user at the Technical University of Munich in Germany.

Watch Now →

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CELL LINE DEVELOPMENT

Generate stable, high-producing monoclonal cell lines with the support of a powerful liquid handler for all dispensing processes.

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ASSAY DEVELOPMENT & OPTIMIZATION

Improve DoE (design of experiments) for drug discovery assays with enhanced automated reagent dispensing.

Gene-Therapy

GENE THERAPY

Generate well-characterized engineered cell clones with greater confidence in single-cell origin with an automated dispensing system.

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SYNTHETIC BIOLOGY

Accelerate the development of new biological parts, systems, and devices at a molecular level.

G.STATION

G.STATION

Fully automated workstation for NGS library preparation from start to finish.

G.PURE

NGS clean up device, automated DNA purification at the push of a button.

CWASH PLUS

C.WASH PLUS

Centrifugal plate washing system, compatible for 96-, 384-, and 1536-well plates.

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Get a Quote or Book a Demo

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The I.DOT can automate the process of dispensing up to 384 liquids into up to 1536 wells of a destination plate! Since there is a lot of flexibility in the use of the platform, we often recommend the use of the I.DOT for steps where liquids are dispensed into 8 or more destination wells at volumes from 4 nL to 30 μL per well.

Yes! Our customers integrate the I.DOT in varying degrees of complexity from simple integrations with an arm and a liquid handler to large robotic workcells capable of processing thousands of samples per day.

The I.DOT can dispense liquids from 0.55 mPa*s (methanol) to 23.32 mPa*s (65% glycerol).

The I.DOT comes equipped with integrated droplet detection that counts the number of droplets dispensed in any given operation. With these data, the I.DOT software will report to you the theoretical volume dispensed by taking the product of the average droplet size and number of droplets counted.