UP.SIGHT

The ultimate upgrade in Cell Line Development.

UP.SIGHT

The ultimate upgrade in cell line development.

Elevate your cell line development workflow

Elevate your cell line development workflow

The UP.SIGHT streamlines cell line development (CLD) workflows by automating labor-intensive and time-consuming steps. We have combined our patented, highly efficient, fast and gentle single-cell dispensing technology with a superfast, high-quality imaging system that provides a full well image and no need for image stitching. Our all-in-one solution enables nozzle imaging and 3D Full Well Imaging for double assurance of clonality from two independent optical apparatuses, leading to a probability of clonality >99.99%.

Probability of clonality >99.99%

8 out of 10 of the best-selling drugs worldwide are developed using biologics. Here is how the UP.SIGHT enables you to optimize your cell line development workflow.

Probability of clonality >99.99%

8 out of 10 of the best-selling drugs worldwide are developed using biologics. Here is how the UP.SIGHT enables you to optimize your cell line development workflow:

Double assurance of clonality

The UP.SIGHT offers two independent methods of assuring monoclonality. First, images are taken at the dispensing nozzle to ensure only one cell is placed in each well, and nonclonal droplets are discarded. Second, the single cells are confirmed once more with 3D Full Well Imaging, a new and innovative method that images the full volume of each well from the point of dispensing using the integrated imager.

All-in-one solution, from single cell to colony

With an integrated imager, the UP.SIGHT enables a full single-cell cloning workflow in one instrument. From gentle single-cell isolation to doubly assured clonality to colony tracking from Day 0, the UP.SIGHT does it all.

Featured workflow

Our extensive product portfolio offers a range of innovative technologies and instruments for significantly increasing the speed, quality and efficiency of your cell line development workflows.

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Transfection

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Cell counting

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Single-cell cloning and double assurance of clonality

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Early suspension culture & upscaling

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Bioreactor 0.2-20 l

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Selection of high producer clones

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1. Transfection

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2. Cell counting

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3. Single-cell cloning and double assurance of clonality

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4. Early suspension culture & upscaling

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5. Bioreactor 0.2-20 l

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6. Selection of high producer clones

Higher yields, greater insights, faster processing

The UP.SIGHT combines our patented single-cell dispensing technology with an industry-leading imaging system for an improved single-cell cloning workflow, enabling higher clonal yields and processing hundreds of clones in under 30 minutes.

Higher yields, greater insights, faster processing

The UP.SIGHT combines our patented single-cell dispensing technology with an industry-leading imaging system for an improved single-cell cloning workflow, enabling higher clonal yields and processing hundreds of clones in under 30 minutes.

Reducing the risk of cross-contamination

The UP.SIGHT’s exclusive EASY.ON cartridge is precisely engineered by microfluidic experts to ensure cell viability with the gentlest handling and is disposable to eliminate the risk of cross-contamination between samples. Plus, setting up your experiments has never been easier as the EASY.ON cartridge is magnetically mounted for quick and easy loading.

Minimizing cell loss

Add an additional layer of optimization with Cell Focusing technology, which gently aligns cells at the center of the dispensing cartridge for superior cell detection. It offers significant improvements when working with rare cell types as this alignment ensures that cells are perfectly captured and measured, reducing cell loss and even increasing processing speeds.

Benefits designed to optimize your workflows

Double assurance of clonality

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Easy to operate and automate

easy to operate and automate
Greater insights

Greater insights

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Integrated Imager

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Faster than ever before

Simplify your CLD workflow

Simplify your CLD workflow

Assurance of clonality

Easy to operate and automate

Simplify your CLD workflow

Faster than ever before

Integrated Imager

Greater insights

Related application note

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